to explore the possible therapeutic value of human chemosignals

Pipette and test tubes

Emma Eliasson and colleagues to work registered ISRCTN registrationIt goals to seek out out whether or not publicity to physique odors will increase the effectiveness of mindfulness remedy in sufferers with depressive and social nervousness signs.

POTION undertaking

The general purpose of POTION is to know how the sense of odor influences human social interplay.

The undertaking will discover social interplay by combining new information concerning the chemical composition of human social chemosignals with a brand new scent-based know-how designed to drive social habits. To do that, the researchers of the POTION undertaking will purpose to resolve three essential issues.

The primary problem is to investigate human chemosignals to determine chemical compounds that carry details about the sender’s emotional state. To this finish, the undertaking focuses on emotions of happiness and concern. It is because these feelings drive strategy and avoidance behaviors, that are the fundamental constructing blocks of social interplay between people of the identical species.

The outcomes can be used to beat the second problem: artificially synthesizing the chemical alerts of those feelings. These synthesized compounds will then be utilized in an progressive, computer-controlled odor supply system that may drive social response methods.

Elixir logo

Elixir emblem

This brings us to the third problem: the event of this groundbreaking machine. How will this work? The machine can be managed in a closed loop the place the social-emotional state of the individuals can be assessed with a brand new computational neural mannequin, and in keeping with this evaluation, the supply system will launch artificial chemosignals that may enhance the individuals’ well-being and feelings. belief.

The POTION system can be carried out and examined in each social and scientific eventualities. The ultimate final result of the undertaking is to suggest a brand new human chemosignal-based therapy for social nervousness.

Why physique odors?

There’s a massive literature on the function of the olfactory system in emotion processing and emotion regulation.

Earlier analysis has proven that folks not solely “odor” feelings in different folks by perceiving different folks’s physique odors, but additionally reply accordingly to emotional physique odors. For instance, it has been proven that publicity to the armpit odor of people that expertise concern causes actions within the facial muscular tissues utilized in expressions of concern, whereas those that are uncovered to the odor of the armpits of people that expertise happiness reply with actions within the facial muscular tissues used to precise true happiness. .

If emotional physique odor can have an effect on the emotional state of the recipient, one might ponder whether it may be used to enhance people’ psychological well being.

Chemosignals as remedy enhancers for social nervousness: pilot research

women talking

girls speaking


on this pilot studyWe purpose to discover whether or not interventions used to deal with psychological well being circumstances similar to social nervousness will be improved with using human chemosignals.

To this finish, we designed a pilot randomized management trial. On this research, 96 girls aged 18-36 with signs of social nervousness accomplished a mindfulness intervention whereas being randomly uncovered to one among 4 circumstances: happiness, concern, or impartial human physique odor, or contemporary air (management situation). Psychological outcomes are measured by questionnaires earlier than and after the intervention (eg, quick model of the State-Trait Nervousness Stock). In the course of the intervention, physiological outcomes are additionally measured, together with pores and skin conductivity and coronary heart fee variability.

potential impression

We hope the POTION undertaking can convey new insights into the mechanism of how human chemosignals have an effect on habits and feelings. It will open up new methods to make use of chemosignals to enhance present therapies and promote social interplay by rising emotions of social connectedness.

As well as, psychological well being problems have an effect on social and emotional well-being and may result in stigma, lack of productiveness, and dear sources wanted for therapy and administration. With our work, we purpose to extend entry to totally different types of therapy that may be performed independently. This has many advantages because it reduces stress on the healthcare system and in addition improves affected person selection concerning out there therapy choices.

Extra data

please go to IKSIR website for extra data or observe the undertaking twitter.


The POTION undertaking and work, European Fee H2020 Framework Programme, Grant No. Funded by 824153.

#discover #therapeutic #human #chemosignals

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